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Funding

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Targeted Therapy

Disease Mutations

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WELCOME TO THE SMITH LAB...
Our group's research aims to integrate modern experimental approaches in structural biology, biophysics, evolutionary bioinformatics, and cell biology to help identify and understand abnormal cancer signalling at both a mechanistic and systems level.
LATEST NEWS
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New bioRxiv preprint describes SPaRTa; a system to study activation of singular GTPases in cells
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Changhwa Jo uses a combined AlphaFold3/biophysics workflow to reveal how AFDN binds SCRIB
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Big team effort: development of macrocyclic peptides that target the allosteric lobe of H/KRAS
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Work in Nat Commun shows MRAS is a pseudoGTPase switch and not like classical RAS
2025
2026
CONTACT US
IRIC | Université de Montréal
2950, Chemin de Polytechnique
Pavillon Marcelle-Coutu, Rm. 4480
Montréal, Québec H3T 1J4
www.iric.ca | www.umontreal.ca |
Lab: (514) 343-6111 x 41294
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