Publication List

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Singh S, G Bernal Astrain, AM Hincapie, M Goudreault and MJ Smith. Complex interplay between RAS GTPases and RASSF effectors regulates subcellular localization of YAP. EMBO Reports 2024; 25: 3574-3600.

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Strakhova R and MJ Smith. Profiling Complex RAS-Effector Interactions Using NMR Spectroscopy. In: Stephen A, Esposito D (eds) KRAS - Methods and Protocols: Methods Molecular Biology 2024; 2797: 195-209.

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Quirion L, A Robert, J Boulais, S Huang, G Bernal Astrain, R Strakhova, CH Jo, Y Kherdjemil, D Faubert, M-P Thibault, M Kmita, JM Baskin, A-C Gingras, MJ Smith and J-F Côté. Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways. Journal of Cell Science 2024; 137 (9): jcs262140.

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Smith MJ. Defining bone fide effectors of RAS GTPases. BioEssays 2023; 45 (9): e2300088.

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Elkholi IE, J Boulais, M-P Thibault, H-D Phan, A Robert, LB Lai, D Faubert, MJ Smith, V Gopalan, and J-F Côté. Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex. Journal of Biological Chemistry 2023; 299 (9): 105123.

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Tran V, S Nahlé, A Robert, I Desanlis, R Killoran, S Ehresmann, M-P Thibault, D Barford, KS Ravichandran, M Sauvageau, MJ Smith, M Kmita & J-F Côté. Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration. Nature Communications 2022; 13 (1): 7077.

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Goudreault M, V Gagné, CH Jo, S Singh, RC Killoran, A-C Gingras and MJ Smith. Afadin couples RAS GTPases to the polarity rheostat Scribble. Nature Communications 2022; 13 (1): 4562. 

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Bernal Astrain G, M Nikolova and MJ Smith. Functional diversity in the RAS subfamily of small GTPases. Biochemical Society Transactions 2022; 50 (2): 921-33.

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Killoran RC and MJ Smith. NMR Detection Methods for Profiling RAS Nucleotide Cycling. In: Rubio I, Prior I (eds) Ras Activity and Signaling. Methods in Molecular Biology 2021; 2262: 169-182.

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Singh S and MJ Smith. RAS GTPase signalling to alternative effector pathways. Biochemical Society Transactions 2020; 48 (5): 2241-2252.

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Dhanaraman T, S Singh, RC Killoran, A Singh, X Xu, J Shifman, and MJ Smith. RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway. Science Signaling 2020; 13 (653): 1-15.

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Chang L, J Yang, CH Jo, A Boland, Z Zhang, SH McLaughlin, A Abu-Thuraia, RC Killoran, MJ Smith*, J-F Côté* and D Barford. Structure of the DOCK2−ELMO1 complex: insights into regulation of the auto-inhibited state by up-stream regulators. Nature Commmunications 2020; 11 (1): 3464. *equal contributions

 

Killoran, RC and MJ Smith. Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel. Journal of Biological Chemistry 2019; 294 (25): 9937-9948.

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Smith MJ*, E Ottoni, N Ishiyama, M Goudreault, A Haman, C Meyer, M Tucholska, G Gasmi-Seabrook, S Menezes, RC Laister, MD Minden, R Marschalek, A-C Gingras, T Hoang and M Ikura*. Evolution of AF6-RAS Association and Implications in Mixed-Lineage Leukemia. Nature Communications 2017; 8 (1): 1099. *co-corresponding

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Spencer-Smith R, A Koide,  Y Zhou, R Eguchi, F Sha,  P Gajwani, D Santana, A Gupta, M Jacobs, E Herrero-Garcia, J Cobbert, H Lavoie, M Smith, T Rajakulendran, E Dowdell, M Nazir Okur, I Dementieva, F Sicheri, M Therrien, JF Hancock, M Ikura, S Koide, and JP O’Bryan. Inhibition of Ras function through targeting an allosteric regulatory site. Nature Chemical Biology 2017; 13: 62-68.

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Fang Z, CB Marshall, JC Yin, MT Mazhab-Jafari, GMC Gasmi-Seabrook, MJ Smith, T Nishikawa, Y Xu, BG Neel and M Ikura. Biochemical Classification of Disease-Associated Mutants of RAS-Like Protein Expressed in Many Tissues (RIT1). Journal of Biological Chemistry 2016; 291 (30): 15641-52.

 

Park S, NR Bin, M Michael Rajah, B Kim, TC Chou, SA Kang, K Sugita, L Parsaud, M Smith, PP Monnier, M Ikura, M Zhen, and S Sugita. Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans. Molecular Biology of the Cell 2016; 27 (4):669-85.

 

Smith MJ, CB Marshall, F Theillet, A Binolfi, P Selenko and M Ikura. Real-time NMR monitoring of biological activities in complex physiological environments. Current Opinion in Structural Biology 2015; 32: 39–47.

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Mazhab-Jafari MT, CB Marshall, MJ Smith, GMC Gasmi-Seabrook, PB Stathopoulos, F Inagaki, LE Kay, BG Neel and M Ikura. Oncogenic and RASopathy-associated KRAS mutations relieve membrane-dependent occlusion of the effector-binding site. Proceedings of the National Academy of Sciences U S A 2015; 112 (21): 6625-30.

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Smith MJ and M Ikura. Integrated RAS Signaling Defined by Parallel NMR Detection of Effectors and Regulators. Nature Chemical Biology 2014; 10(3): 223-30.

 

Findlay GM, MJ Smith, F Lanner, M Hsiung, GD Gish, T Kaneko, H Huang, RD Bagshaw, T Ketela, J Moffat, M Ikura, S Li, S Sidhu, J Rossant and T Pawson. Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate. Cell 2013; 152(5): 1008-20.

 

Smith MJ, BG Neel and M Ikura. NMR-Based Functional Profiling of RASopathies and Oncogenic RAS Mutations. Proceedings of the National Academy of Sciences U S A 2013; 110(12): 4574-9.

 

Long D, CB Marshall, G Bouvignies, MT Mazhab-Jafari, MJ Smith, M Ikura and LE Kay. A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues. Angewandte Chemie International 2013; 52(41): 10771-4.

 

Marshall CB, D Meiri, MJ Smith, MT Mazhab-Jafari, GM Gasmi-Seabrook, R Rottapel, V Stambolic and M Ikura. Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts. Methods 2012; 57(4): 473-85.

 

Smith MJ, WR Hardy, G-Y Li, M Goudreault, S Hersch, P Metalnikov, A Starostine, T Pawson and M Ikura. The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. EMBO Journal 2010; 29(5): 884-96.

 

Ishiyama N, SH Lee, S Liu, G-Y Li, MJ Smith, LF Reichardt and M Ikura. Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell 2010; 141(1): 117-28.

 

Mazhab-Jafari MT, CB Marshall, M Smith, GM Gasmi-Seabrook, V Stambolic, R Rottapel, BG Neel and M Ikura. Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics. Journal of Biological Chemistry 2010; 285(8): 5132-6.

 

Murphy JM, DF Flemming-Hansen, S Wiesner, DR Muhandiram, M Borg, MJ Smith, F Sicheri, LE Kay, JD Forman-Kay and T Pawson. Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. Journal of Molecular Biology 2009; 393(2): 409-24.

 

Stenqvist A, TK Lundgren, MJ Smith, O Hermanson, G Castelo-Branco, T Pawson and P Ernfors. Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok. Neuroscience Letters 2008; 435(1): 11-6.

 

Jones N, WR Hardy, MB Friese, C Jorgensen, MJ Smith, NM Woody, SJ Burden and T Pawson. Analysis of a novel Shc family adaptor protein, ShcD, that associates with Muscle-Specific Kinase (MuSK). Molecular and Cellular Biology 2007; 27(13): 4759-73.

 

Smith MJ, WR Hardy, JM Murphy, N Jones and T Pawson. Screening for PTB Domain Binding Partners and Ligand Specificity Using Proteome-Derived NPxY Peptide Arrays. Molecular and Cellular Biology 2006; 26(22): 8461-74.

 

Lundgren TK, RP Scott, M Smith, T Pawson and P Ernfors. Engineering the recruitment of PTB adaptor proteins reveals distinct roles for Ret receptor-mediated cell survival. Journal of Biological Chemistry 2006; 281(40): 29886-96.

 

Smith MJ, S Kulkarni and T Pawson. FF Domains of CA150 Bind Transcription and Splicing Factors Through Multiple Weak Interactions. Molecular and Cellular Biology 2004; 24(21): 9274-85.

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